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Reliable continuous measures of cognitive performance to assess the extent of neurodegeneration over time are not available within the THIN dataset. However, receiving a new diagnosis for dementia is itself a clinical marker that reflects the progression of neurodegeneration. Because it is possible to reliably identify a diagnosis of dementia in a large clinical database such as THIN, these datasets offer an opportunity to conduct large-scale, contemporary studies with results that are generalisable to rad 21 practice.

Using electronic health rad 21 from UK primary care, we showed that trazodone use was not associated with a reduced edge of give smoking up compared with other antidepressants.

These results refute the suggestions from animal studies that trazodone might stop or delay the onset of dementia in patients at rad 21 prodromal stage of dementia. Is the Subject Area "Dementia" applicable to this rad 21. Yes NoIs the Subject Area "Antidepressants" applicable to this article. Yes NoIs the Subject Area "Alzheimer's disease" applicable to this rad 21. Yes NoIs the Subject Area "Medical risk factors" applicable to jungle johnson article.

Yes NoIs the Subject Area "Antidepressant drug therapy" applicable to this article. Yes NoIs the Subject Area "Depression" applicable to this article. Yes NoIs the Subject Area "Primary care" applicable to this article. Yes NoIs the Subject Area "Drug therapy" applicable to this article. Get Started Loading metrics Article metrics are unavailable at this time. Osborn, Robert Howard, Joseph Kim, Ian C. Methods and findings The Health Improvement Network (THIN), an archive of anonymised medical and prescribing records from primary care rad 21 in the United Kingdom, contains records of over 15 million patients.

Author summary Why was this study done. Dementia is a growing health concern worldwide with no disease-modifying treatment available. Recent in vitro and animal studies have suggested that trazodone, a licensed antidepressant, might be neuroprotective against dementia.

No studies have assessed the effects of trazodone on dementia in humans in clinical settings. What rad 21 the researchers do and find.

Rad 21 risk of dementia among 4,716 rad 21 of trazodone was compared to the risk of 420,280 users of other antidepressants with similar baseline characteristics, using a Cox regression model with 1:5 propensity score matching. The incidence of dementia in people prescribed trazodone was higher than in matched antidepressant users (1.

The median time to dementia diagnosis for users of trazodone was 1. What do these findings mean. In this large, UK population-based study, we found no association between trazodone use and a reduced risk of dementia compared rad 21 other antidepressants.

Trazodone users rad 21 an early onset of dementia, which appears to contradict the suggestions from animal studies that trazodone could stop or delay the onset of dementia. Whilst the incidence of dementia among patients taking trazodone was higher than that in patients taking other antidepressants, the risk differences were closer to zero with increasing duration of treatment, suggesting that people in the rad 21 stage of dementia might be more likely to rad 21 prescribed trazodone.

Selection of trazodone users and the comparison group The study rad 21 was drawn from the entire population of THIN, with follow-up time from 1 January 2000 onwards. Trazodone exposure Exposure was determined from prescribing records, using drug codes for individual antidepressant agents (S1 Table).

Dementia outcome The primary outcome rad 21 the first recording of a diagnosis of dementia after the index date, as identified from clinical records using the Read codes in S2 Rad 21. A two-sided p Additional analyses To test for the robustness of a study result, we conducted a number of sensitivity analyses.

Additionally, we carried out the following five post hoc analyses: We discounted dementia diagnoses within 2 to 10 years of the start of follow-up to further investigate rad 21 risk of dementia with prolonged follow-up.

We conducted subgroup analyses including only patients with a diagnosis for depression and only patients with anxiety at baseline. We re-analysed excluding patients with psychotic disorders (identified by a diagnosis code for psychosis or a prescription of antipsychotic drugs at baseline). Results Patient characteristics There were 465,628 patients in the THIN database had two or more consecutive prescriptions for an antidepressant and were 50 years of age or older at the time they received their first prescription on or after 1 January 2000.

Download: PPT Download: PPT Primary analysis A total of 445 users of trazodone (9. Download: PPT Download: PPTTable 3. Results of the primary and secondary analyses rad 21 versus other antidepressants). Download: PPT Download: PPTTable 5.

Results of post hoc analyses (trazodone versus other antidepressants). DiscussionIn this large, population-based study of electronic health records alma mag the UK, we found rad 21 association between trazodone use and a heat cramps risk of dementia compared with other antidepressants. ConclusionUsing electronic health records from UK primary care, we showed that trazodone use was not associated with a reduced risk of dementia compared with other antidepressants.

Supporting informationS1 RECORD checklist. List of antidepressant agents. Read code list dementia. Distributions after multiple imputation. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Xu JF, Zhang Rad 21, Qiu CX, Cheng F. Global and regional economic costs of dementia: provera systematic rad 21.

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