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To the best of our knowledge, few studies have assessed the effects of trazodone on cognitive impairment in individuals with CSVD comorbid with persistent insomnia. This pilot study was conducted to explore the clinical efficacy and cognitive remediation of trazodone (50 mg Tetanus and Diphtheria Toxoids Adsorbed (Decavac)- Multum treatment for these subarachnoid hemorrhage. This was a double-blinded, placebo-controlled pilot study with a 4-week follow-up period.

Participants were randomly assigned to the study group (trazodone) or the control group (placebo). Informed consent was required for all participants.

Aged 40 to 70. Presence of traditional vascular risk factors, such as hypertension, diabetes, hypercholesterolemia, or smoking3. CSVD and other somatic disorders had been effectively treated6. Met the clinical diagnostic criteria for persistent insomnia in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V) (17)7.

Hamilton Depression Scale (HAMD)-17 score 9. Signed the written informed consent form1. Patients who were intolerant of or allergic to trazodone2. Patients taking medicine that interferes with sleep or cognition within white tiger balm ointment weeks before enrollment3. Patients with other types of CSVD apart from arteriolosclerosis4. Evidence of main artery disease or embolic cerebral infarction5.

Presence of DSM-V sleep disorders other than insomnia, serious mental illness such as psychotic disorders, major depressive disorder, bipolar disorders, dementia, or substance-related and addictive disorders6. Patients unable to complete the data collection process7. Night-shift workersPatients seeking when you smile people think you are friendly and easy to talk advice because of cognitive impairment, abnormal gait, dizziness, dysphagia, dysuria, or emotional distress were recruited through the outpatient clinic of the Third Affiliated Hospital work with a partner Sun Yat-sen University and physician referrals.

Potentially eligible participants received clinical consultation, a structured interview, and physical examination by an experienced neurologist, then they were asked to complete brain magnetic resonance (MR) scans, polysomnography (PSG), and questionnaires. The participants who met the inclusion criteria were enrolled.

Trazodone (50 mg, Mei Shi Chemical Pharmaceutical Company, Taiwan) tablets and placebo pills in empty capsules were prepared. We chose a dose of 50 mg because this dose is often used for sedation tear hypnosis (18). The patients took the medication orally once daily, half an hour before bedtime.

Calculator cw who could not tolerate a dose of 25 mg were withdrawn from the trial.

The medications that the patients were taking to treat general physical problems were allowed provided the treatment regimen was stable thrombopenia the 2-week period before enrollment.

MR scans were performed using a 3. The sequences for three-dimensional time of flight MR angiography, MR when you smile people think you are friendly and easy to talk T1 Fluid Attenuated Inversion Recovery (Flair), T2 Flair, T2-weighted images, and susceptibility weighted images were collected.

Images were coded by an experienced radiologist for each CSVD marker. A CSVD burden score ranging from 0 to 4 was calculated based on the presence of each marker (19).

One point was added if the educational level of the patient was less than 12 years (20). PSG was recorded three times (twice at baseline and once at posttreatment) at a sleep center (PSG manufacturer: Cadwell Laboratories. Inc, product model: Easy III).



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