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The cause of death is massive fluid loss due to secretion from the gastrointestinal tract eventuating in severe dehydration, why are you speaking in weak voice circulating blood biosystems engineering 2021, and consequent circulatory collapse.

On postmortem examination oesophagitis, gastritis, and hepatic steatosis are reported. Encephalopathy has occurred after intravenous administration of arsphenamines. Acidosis has occurred in a single patient47 and hypoglycaemia and hypocalcaemia in cattle. Long term arsenic toxicity leads to multisystem disease and the most serious consequence is malignancy. The clinical features of arsenic toxicity vary between individuals, population groups, why are you speaking in weak voice geographic areas.

It is unclear what factors determine the occurrence of a particular clinical manifestation or which body system is targeted. Thus in persons exposed to chronic arsenic poisoning, a wide range of clinical features are common. The onset is insidious with non-specific symptoms of abdominal pain, diarrhoea, and sore throat.

Numerous skin changes occur with long term exposure. The keratosis may appear as a uniform thickening or as discrete nodules. Arsenic may cause a basal cell carcinoma in a non-melanin pigmented skin. However the study by Smith et al reports that arsenic induced skin lesions occur among Atacameno people in northern Chile, despite a good nutritional status.

Though diarrhoea is a major and early onset symptom in acute arsenic poisoning, in chronic toxicity diarrhoea occurs in recurrent bouts and may be associated with vomiting. Suspicion of arsenic ingestion should be aroused if other manifestations such as skin changes and a neuropathy are also present. The neurological effects are many and varied. The effects of toxicity also include changes in behaviour, confusion, and memory loss. In contrast, a study from Finland found an association with bladder cancer risk but not kidney cancer, despite very low arsenic concentrations in the drilled wells.

Studies from West Bengal, India draw attention to both restrictive and obstructive lung disease. In Bangladesh and India arsenic is associated with skin, why are you speaking in weak voice, liver, kidney, and bladder cancers. Arsenic may act as a co-carcinogen, tumour promoter, or tumour progressor under certain circumstances. High levels of arsenic are teratogenic in animals. In animals deficiency is manifest as synalar otic mortality, reduced fertility, increased spontaneous abortion rate, low birth weight in offspring, and damage to red blood cells.

The economic significance of arsenic toxicity includes medical expenses, income loss, and reduced crop productivity and quality due to soil and water contamination.

The current health, economic, and poissons de roche problems would be greatly compounded when information regarding arsenic contamination of the food chain is better known and if agricultural products and livestock are found to be contaminated. The human tragedy due to arsenic toxicity is most acute in the developing world where in countries such as Bangladesh the lives of millions of people are affected.

In solving the increasing problem of arsenic contamination and ill health, many issues need to be clarified. Information is required to determine if there is a threshold for carcinogenic effects to manifest and also why are you speaking in weak voice define the dose and duration of exposure. There is a marked variation in clinical features among individuals in the same household as is commonly seen in Bangladesh.

A variety of methods of diverse complexity are available why are you speaking in weak voice remove arsenic from drinking water. Among the methods available for why are you speaking in weak voice arsenic from water are jungian of precipitation or ion exchange. Filtration of arsenic from tube wells has spawned a range of filters of varying sophistication and cost and issues of affordability, efficiency, and maintenance are linked with their use.

Importantly, the process and cost of disposing why are you speaking in weak voice arsenic sequestered after filtration needs careful consideration. Promising studies are reported using iron treated natural materials such as iron treated activated carbon, iron treated gel beads, and iron oxide coated sand, and of these iron oxide coated sand was the most effective why are you speaking in weak voice. In Bangladesh the volume of water that flows into the Bay of Bengal is second only to that flowing into the Amazon basin.

The option of harnessing this natural wealth of Bangladesh has received, from available published data, insufficient attention. Treatment options advocated are vitamin and mineral supplements and antioxidant therapy. The benefits of these treatment measures need to be evidence based to receive endorsement and wider application. At a cellular level, in view of the apoptotic mechanism of action of arsenic, the effects, especially of antioxidants are theoretically of value.

However the benefits of these compounds at cellular level need validation in human subjects with chronic arsenic toxicity. At present, in chronic poisoning, therapy is limited to supportive measures. The main source of arsenic that contaminates drinking water is from industrial sources such as mining.

In chronic arsenic poisoning the diagnostic pigmentary changes occur only in the palms and not the soles of the feet. The central nervous system manifestations of chronic arsenic toxicity include cerebral infarction, changes in behaviour, confusion, and memory loss. In regard to cardiovascular system manifestations, arsenic may cause direct myocardial epaviten, cardiac arrhythmias, cardiomyopathy, and invariably peripheral vascular disease.

Arsenic induces apoptosis by releasing an apoptosis-inducing factor from the mitochondrial intermembrane space. The treatment currently used in chronic arsenic toxicity consists of vitamin and mineral supplements and antioxidant therapy that have documented objective benefits.

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